Remedies for coughs and colds. Mucolytics. Acetylcysteine.
N-acetyl-L-cysteine (AC) has a marked mucolytic effect on mucous and mucopurulent secretions due to depolymerization of mucoprotein complexes and nucleic acids, which give viscosity to hyaline and purulent components of sputum and other secretions. Additional properties: reduction of induced mucocyte hyperplasia, increase of surfactant production due to stimulation of type II pneumocytes, stimulation of activity of mucociliary apparatus, which furthers the improvement of mucociliary clearance. AC also has a direct antioxidant effect due to the presence of a nucleophilic free thiol group (SH), which can directly interact with the electrophilic groups of oxidative radicals. Of particular interest is the fact that AC prevents the inactivation of α-1-antitrypsin – an enzyme that inhibits elastase – by hydrochloric acid (HOCl) - a strong oxidant produced by myeloperoxidase of active phagocytes.
Treatment of acute and chronic diseases of the bronchopulmonary system, accompanied by increased sputum production.
400-600 mg per day, divided into 1-3 administrations depending on clinical conditions.
2-6 years old: 200-400 mg per day, divided into 1-3 administrations;
6-12 years old: 400-600 mg per day, divided into 1-3 administrations;
from the age of 12 years - doses as for adults.
Effervescent tablets 200 mg shall be dissolved in 1/3 glass of water.
Additional fluid intake enhances the mucolytic effect of the medicinal product.
The duration of treatment shall be determined by the doctor on a case by case basis, depending on the nature of the disease (acute or chronic). The drug should not be taken for more than 4-5 days without consulting a doctor.