Analgesics and antipyretics
Non-narcotic analgesic. It selectively inhibits COX by affecting pain and thermoregulation centers. In inflamed tissues, cellular peroxidases neutralize the effect of paracetamol on COX, which explains the slight anti-inflammatory effect. There is no effect on the synthesis of prostaglandins in peripheral tissues, which provides for the absence of negative effects of paracetamol on water-salt metabolism (retention of sodium and water) and the mucous membrane of the gastrointestinal tract. The possibility of formation of methemoglobin and sulfhemoglobin is unlikely.
Low and moderate intensity pain syndrome of different genesis (headache, including migraine and tension headache, back pain, rheumatic pain, muscle pain, periodic pain in women, neuralgic pain, toothache). Relief of cold and flu symptoms, such as fever, body pain.
For oral use. Take with plenty of fluids, 1-2 hours after eating (taking immediately after a meal will prolong the absorption time).
For adults and children above 12 years of age (body weight over 40 kg), a single dose is 400-1,000 mg; dosage frequency - up to 4 times a day, if necessary. Do not take more than 4,000 mg within 24 hours. For patients with impaired liver or kidney function, for elderly patients, the daily dose should be reduced and the interval between doses should be increased.
Children above 3 years of age should be prescribed 10-15 mg/kg (single dose). Administration may be repeated after 6 hours (up to 4 times a day) if necessary.
The maximum daily dose for children from 3 to 6 years (up to 22 kg) is 1,000 mg, from 6 to 9 years (up to 30 kg) 1,500 mg, from 9 to 12 years (up to 40 kg) 2,000 mg. The maximum duration of the use for children without medical advice is 3 days.