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Simple agents of angiotensin II antagonists. Valsartan.

Valsartan is an active specific angiotensin II receptor antagonist for oral use. It selectively influences AT1 subtype receptors responsible for the known effects of angiotensin II. Elevated plasma angiotensin II levels after AT1 receptor blockade by valsartan can stimulate the unblocked AT2 receptor that balances the effect of the AT1 receptor. Valsartan does not show any partial agonist activity against the AT1 receptor, but has much greater (approximately 20,000 times) affinity for the AT1 receptor than for the AT2 receptor.

Arterial hypertension.

Treatment of arterial hypertension in adults and children over 6 years of age.

Post-infarction condition.

Treatment of clinically stable adult patients with symptomatic heart failure or asymptomatic left ventricular systolic dysfunction after a recent (12 hours - 10 days) myocardial infarction.

Heart failure.

Treatment of symptomatic heart failure in adult patients when ACE inhibitors cannot be used, or as adjunctive therapy with ACE inhibitors when β-blockers cannot be used.

The medicinal product can be used regardless of meals, tablets should be washed down with water.

Dosage.

Arterial hypertension.

The recommended starting dose of Valsartan is 80 mg once daily. The antihypertensive effect is achieved within 2 weeks, and the maximum effect - within 4 weeks. In some patients with inadequately controlled blood pressure, the dose may be increased to 160 mg and to a maximum of 320 mg.

The drug can also be used with other antihypertensive drugs. Concomitant use of diuretics, such as hydrochlorothiazide, will further lower blood pressure in patients.

Specialized edition for medical institutions and doctors.